home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-06 | 297.4 KB |
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MacOS 8.1
|
Win98
|
DOS
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
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|00000010| 00 00 16 00 00 00 30 30 | 00 00 00 01 9c 05 00 00 |......00|........|
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|00000280| 00 00 00 01 90 0e 02 00 | 5b 0b 00 00 34 35 00 00 |........|[...45..|
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|00000380| c3 dc 02 00 de 06 00 00 | 36 33 00 00 00 01 a1 e3 |........|63......|
|00000390| 02 00 92 09 00 00 36 34 | 00 00 00 01 33 ed 02 00 |......64|....3...|
|000003a0| 66 0a 00 00 36 35 00 00 | 00 01 99 f7 02 00 5d 0c |f...65..|......].|
|000003b0| 00 00 36 36 00 00 00 01 | f6 03 03 00 91 0f 00 00 |..66....|........|
|000003c0| 36 37 00 00 00 01 87 13 | 03 00 52 0b 00 00 36 38 |67......|..R...68|
|000003d0| 00 00 00 01 d9 1e 03 00 | dc 08 00 00 36 39 00 00 |........|....69..|
|000003e0| 00 01 b5 27 03 00 ae 0a | 00 00 37 30 00 00 00 01 |...'....|..70....|
|000003f0| 63 32 03 00 82 0a 00 00 | 37 31 00 00 00 01 e5 3c |c2......|71.....<|
|00000400| 03 00 20 0b 00 00 37 32 | 00 00 00 01 05 48 03 00 |.. ...72|.....H..|
|00000410| 27 0a 00 00 37 33 00 00 | 00 01 2c 52 03 00 25 0a |'...73..|..,R..%.|
|00000420| 00 00 37 34 00 00 00 01 | 51 5c 03 00 c7 0b 00 00 |..74....|Q\......|
|00000430| 37 35 00 00 00 01 18 68 | 03 00 e0 0a 00 00 37 36 |75.....h|......76|
|00000440| 00 00 00 01 f8 72 03 00 | 6a 09 00 00 37 37 00 00 |.....r..|j...77..|
|00000450| 00 01 62 7c 03 00 e5 0b | 00 00 37 38 00 00 00 01 |..b|....|..78....|
|00000460| 47 88 03 00 3b 0b 00 00 | 37 39 00 00 00 01 82 93 |G...;...|79......|
|00000470| 03 00 10 07 00 00 38 30 | 00 00 00 01 92 9a 03 00 |......80|........|
|00000480| 8e 0a 00 00 38 31 00 00 | 00 01 20 a5 03 00 f8 0d |....81..|.. .....|
|00000490| 00 00 38 32 00 00 00 01 | 18 b3 03 00 c5 0d 00 00 |..82....|........|
|000004a0| 38 33 00 00 00 01 dd c0 | 03 00 6c 0e 00 00 38 34 |83......|..l...84|
|000004b0| 00 00 00 01 49 cf 03 00 | a3 0c 00 00 38 35 00 00 |....I...|....85..|
|000004c0| 00 01 ec db 03 00 05 0d | 00 00 38 36 00 00 00 01 |........|..86....|
|000004d0| f1 e8 03 00 4b 0b 00 00 | 38 37 00 00 00 01 3c f4 |....K...|87....<.|
|000004e0| 03 00 1e 0d 00 00 38 38 | 00 00 00 01 5a 01 04 00 |......88|....Z...|
|000004f0| 63 10 00 00 38 39 00 00 | 00 01 bd 11 04 00 03 0c |c...89..|........|
|00000500| 00 00 39 30 00 00 00 01 | c0 1d 04 00 7b 0d 00 00 |..90....|....{...|
|00000510| 39 31 00 00 00 01 3b 2b | 04 00 df 0b 00 00 39 32 |91....;+|......92|
|00000520| 00 00 00 01 1a 37 04 00 | db 0c 00 00 39 33 00 00 |.....7..|....93..|
|00000530| 00 01 f5 43 04 00 43 0f | 00 00 39 34 00 00 00 01 |...C..C.|..94....|
|00000540| 38 53 04 00 a9 0b 00 00 | 39 35 00 00 00 01 e1 5e |8S......|95.....^|
|00000550| 04 00 86 0f 00 00 39 36 | 00 00 00 01 67 6e 04 00 |......96|....gn..|
|00000560| 87 08 00 00 39 37 00 00 | 00 01 ee 76 04 00 12 0e |....97..|...v....|
|00000570| 00 00 39 38 00 00 00 01 | 00 85 04 00 b9 0e 00 00 |..98....|........|
|00000580| 39 39 00 00 00 01 b9 93 | 04 00 0f 12 00 00 00 00 |99......|........|
|00000590| 00 00 00 00 c8 a5 04 00 | 00 00 00 00 24 55 6e 69 |........|....$Uni|
|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 31 30 37 30 30 7d |que_ID{Y|RB10700}|
|000005b0| 0d 0a 24 54 69 74 6c 65 | 7b 50 65 6e 74 6f 78 69 |..$Title|{Pentoxi|
|000005c0| 66 79 6c 6c 69 6e 65 20 | 69 6e 20 41 63 75 74 65 |fylline |in Acute|
|000005d0| 20 4e 6f 6e 68 65 6d 6f | 72 72 68 61 67 69 63 20 | Nonhemo|rrhagic |
|000005e0| 53 74 72 6f 6b 65 3a 20 | 20 41 20 52 61 6e 64 6f |Stroke: | A Rando|
|000005f0| 6d 69 7a 65 64 2c 20 50 | 6c 61 63 65 62 6f 2d 20 |mized, P|lacebo- |
|00000600| 43 6f 6e 74 72 6f 6c 6c | 65 64 20 44 6f 75 62 6c |Controll|ed Doubl|
|00000610| 65 2d 42 6c 69 6e 64 20 | 54 72 69 61 6c 7d 0d 0a |e-Blind |Trial}..|
|00000620| 24 41 75 74 68 6f 72 7b | 48 73 75 2c 20 43 59 0d |$Author{|Hsu, CY.|
|00000630| 0a 4e 6f 72 72 69 73 2c | 20 4a 57 0d 0a 48 6f 67 |.Norris,| JW..Hog|
|00000640| 61 6e 2c 20 45 4c 0d 0a | 42 6c 61 64 69 6e 2c 20 |an, EL..|Bladin, |
|00000650| 50 0d 0a 44 69 6e 73 64 | 61 6c 65 2c 20 48 42 0d |P..Dinsd|ale, HB.|
|00000660| 0a 59 61 74 73 75 2c 20 | 46 4d 0d 0a 45 61 72 6e |.Yatsu, |FM..Earn|
|00000670| 65 73 74 2c 20 4d 50 0d | 0a 53 63 68 65 69 6e 62 |est, MP.|.Scheinb|
|00000680| 65 72 67 2c 20 50 0d 0a | 43 61 70 6c 61 6e 2c 20 |erg, P..|Caplan, |
|00000690| 4c 52 0d 0a 4b 61 72 70 | 2c 20 48 52 0d 0a 53 77 |LR..Karp|, HR..Sw|
|000006a0| 61 6e 73 6f 6e 2c 20 50 | 44 0d 0a 46 65 6c 64 6d |anson, P|D..Feldm|
|000006b0| 61 6e 2c 20 52 47 0d 0a | 43 6f 68 65 6e 2c 20 4d |an, RG..|Cohen, M|
|000006c0| 4d 0d 0a 4d 61 79 6d 61 | 6e 2c 20 43 49 0d 0a 43 |M..Mayma|n, CI..C|
|000006d0| 6f 62 65 72 74 2c 20 42 | 0d 0a 53 61 76 69 74 73 |obert, B|..Savits|
|000006e0| 6b 79 2c 20 4a 50 0d 0a | 50 65 6e 74 6f 78 69 66 |ky, JP..|Pentoxif|
|000006f0| 79 6c 6c 69 6e 65 20 53 | 74 75 64 79 20 47 72 6f |ylline S|tudy Gro|
|00000700| 75 70 7d 0d 0a 24 41 66 | 66 69 6c 69 61 74 69 6f |up}..$Af|filiatio|
|00000710| 6e 7b 4d 65 64 20 55 6e | 69 76 20 6f 66 20 53 6f |n{Med Un|iv of So|
|00000720| 75 74 68 20 43 61 72 6f | 6c 69 6e 61 2c 20 43 68 |uth Caro|lina, Ch|
|00000730| 61 72 6c 65 73 74 6f 6e | 7d 0d 0a 24 4a 6f 75 72 |arleston|}..$Jour|
|00000740| 6e 61 6c 7b 53 74 72 6f | 6b 65 7d 0d 0a 24 56 6f |nal{Stro|ke}..$Vo|
|00000750| 6c 75 6d 65 7b 31 39 7d | 0d 0a 24 50 61 67 65 7b |lume{19}|..$Page{|
|00000760| 37 31 36 2d 37 32 32 7d | 0d 0a 24 44 61 74 65 7b |716-722}|..$Date{|
|00000770| 4a 75 6e 65 20 31 39 38 | 38 7d 0d 0a 24 59 42 56 |June 198|8}..$YBV|
|00000780| 6f 6c 7b 31 39 39 30 20 | 59 65 61 72 20 42 6f 6f |ol{1990 |Year Boo|
|00000790| 6b 20 6f 66 20 46 61 6d | 69 6c 79 20 50 72 61 63 |k of Fam|ily Prac|
|000007a0| 74 69 63 65 7d 0d 0a 24 | 43 68 61 70 74 65 72 7b |tice}..$|Chapter{|
|000007b0| 38 2d 36 31 7d 0d 0a 24 | 59 42 45 64 69 74 6f 72 |8-61}..$|YBEditor|
|000007c0| 7b 44 72 73 2e 20 52 61 | 6b 65 6c 2c 20 41 76 61 |{Drs. Ra|kel, Ava|
|000007d0| 6e 74 2c 20 44 72 69 73 | 63 6f 6c 6c 2c 20 50 72 |nt, Dris|coll, Pr|
|000007e0| 69 63 68 61 72 64 2c 20 | 61 6e 64 20 53 6d 69 74 |ichard, |and Smit|
|000007f0| 68 7d 0d 0a 24 54 61 62 | 6c 65 7b 7d 0d 0a 24 43 |h}..$Tab|le{}..$C|
|00000800| 6f 6d 6d 65 6e 74 61 74 | 6f 72 7b 52 2e 45 2e 20 |ommentat|or{R.E. |
|00000810| 52 61 6b 65 6c 2c 20 4d | 2e 44 2e 7d 0d 0a 0d 0a |Rakel, M|.D.}....|
|00000820| 43 6f 70 79 72 69 67 68 | 74 20 28 63 29 20 59 65 |Copyrigh|t (c) Ye|
|00000830| 61 72 62 6f 6f 6b 20 4d | 65 64 69 63 61 6c 20 50 |arbook M|edical P|
|00000840| 75 62 6c 69 73 68 65 72 | 73 2c 20 49 6e 63 2e 2c |ublisher|s, Inc.,|
|00000850| 20 31 39 39 30 0d 0a 0d | 0a 31 39 39 30 20 59 65 | 1990...|.1990 Ye|
|00000860| 61 72 20 42 6f 6f 6b 20 | 6f 66 20 46 61 6d 69 6c |ar Book |of Famil|
|00000870| 79 20 50 72 61 63 74 69 | 63 65 20 28 52 29 0d 0a |y Practi|ce (R)..|
|00000880| 0d 0a 43 68 61 70 74 65 | 72 20 38 2d 2d 44 69 73 |..Chapte|r 8--Dis|
|00000890| 65 61 73 65 73 20 6f 66 | 20 74 68 65 20 43 69 72 |eases of| the Cir|
|000008a0| 63 75 6c 61 74 6f 72 79 | 20 53 79 73 74 65 6d 0d |culatory| System.|
|000008b0| 0a 0d 0a 43 65 72 65 62 | 72 6f 76 61 73 63 75 6c |...Cereb|rovascul|
|000008c0| 61 72 20 44 69 73 65 61 | 73 65 0d 0a 0d 0a 2d 2d |ar Disea|se....--|
|000008d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000008e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000008f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000900| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000910| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 50 65 |--------|----..Pe|
|00000920| 6e 74 6f 78 69 66 79 6c | 6c 69 6e 65 20 69 6e 20 |ntoxifyl|line in |
|00000930| 41 63 75 74 65 20 4e 6f | 6e 68 65 6d 6f 72 72 68 |Acute No|nhemorrh|
|00000940| 61 67 69 63 20 53 74 72 | 6f 6b 65 3a 20 20 41 20 |agic Str|oke: A |
|00000950| 52 61 6e 64 6f 6d 69 7a | 65 64 2c 20 50 6c 61 63 |Randomiz|ed, Plac|
|00000960| 65 62 6f 2d 0d 0a 43 6f | 6e 74 72 6f 6c 6c 65 64 |ebo-..Co|ntrolled|
|00000970| 20 44 6f 75 62 6c 65 2d | 42 6c 69 6e 64 20 54 72 | Double-|Blind Tr|
|00000980| 69 61 6c 0d 0a 0d 0a 48 | 73 75 20 43 59 3b 20 4e |ial....H|su CY; N|
|00000990| 6f 72 72 69 73 20 4a 57 | 3b 20 48 6f 67 61 6e 20 |orris JW|; Hogan |
|000009a0| 45 4c 3b 20 42 6c 61 64 | 69 6e 20 50 3b 20 44 69 |EL; Blad|in P; Di|
|000009b0| 6e 73 64 61 6c 65 20 48 | 42 3b 20 59 61 74 73 75 |nsdale H|B; Yatsu|
|000009c0| 20 46 4d 3b 20 45 61 72 | 6e 65 73 74 20 4d 50 3b | FM; Ear|nest MP;|
|000009d0| 0d 0a 53 63 68 65 69 6e | 62 65 72 67 20 50 3b 20 |..Schein|berg P; |
|000009e0| 43 61 70 6c 61 6e 20 4c | 52 3b 20 4b 61 72 70 20 |Caplan L|R; Karp |
|000009f0| 48 52 3b 20 53 77 61 6e | 73 6f 6e 20 50 44 3b 20 |HR; Swan|son PD; |
|00000a00| 46 65 6c 64 6d 61 6e 20 | 52 47 3b 20 43 6f 68 65 |Feldman |RG; Cohe|
|00000a10| 6e 20 4d 4d 3b 20 4d 61 | 79 6d 61 6e 20 43 49 3b |n MM; Ma|yman CI;|
|00000a20| 0d 0a 43 6f 62 65 72 74 | 20 42 3b 20 53 61 76 69 |..Cobert| B; Savi|
|00000a30| 74 73 6b 79 20 4a 50 3b | 20 66 6f 72 20 74 68 65 |tsky JP;| for the|
|00000a40| 20 50 65 6e 74 6f 78 69 | 66 79 6c 6c 69 6e 65 20 | Pentoxi|fylline |
|00000a50| 53 74 75 64 79 20 47 72 | 6f 75 70 0d 0a 28 4d 65 |Study Gr|oup..(Me|
|00000a60| 64 20 55 6e 69 76 20 6f | 66 20 53 6f 75 74 68 20 |d Univ o|f South |
|00000a70| 43 61 72 6f 6c 69 6e 61 | 2c 20 43 68 61 72 6c 65 |Carolina|, Charle|
|00000a80| 73 74 6f 6e 29 0d 0a 53 | 74 72 6f 6b 65 20 31 39 |ston)..S|troke 19|
|00000a90| 3a 37 31 36 2d 37 32 32 | 2c 20 4a 75 6e 65 20 31 |:716-722|, June 1|
|00000aa0| 39 38 38 0d 0a 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |988..---|--------|
|00000ab0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000ac0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000ad0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000ae0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000af0| 2d 2d 2d 0d 0a 0d 0a 41 | 62 73 74 72 61 63 74 0d |---....A|bstract.|
|00000b00| 0a 0d 0a 20 20 20 20 20 | 54 68 65 20 74 68 65 72 |... |The ther|
|00000b10| 61 70 65 75 74 69 63 20 | 6d 6f 64 69 66 69 63 61 |apeutic |modifica|
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|00000b30| 73 63 6f 73 69 74 79 20 | 68 61 73 20 62 65 65 6e |scosity |has been|
|00000b40| 20 70 72 6f 70 6f 73 65 | 64 20 61 73 20 61 6e 0d | propose|d as an.|
|00000b50| 0a 61 6c 74 65 72 6e 61 | 74 69 76 65 20 74 68 65 |.alterna|tive the|
|00000b60| 72 61 70 79 20 66 6f 72 | 20 61 63 75 74 65 20 69 |rapy for| acute i|
|00000b70| 73 63 68 65 6d 69 63 20 | 73 74 72 6f 6b 65 2e 20 |schemic |stroke. |
|00000b80| 20 50 65 6e 74 6f 78 69 | 66 79 6c 6c 69 6e 65 20 | Pentoxi|fylline |
|00000b90| 28 50 54 58 29 2c 20 61 | 0d 0a 68 65 6d 6f 72 68 |(PTX), a|..hemorh|
|00000ba0| 65 6f 6c 6f 67 69 63 20 | 61 67 65 6e 74 2c 20 69 |eologic |agent, i|
|00000bb0| 6d 70 72 6f 76 65 73 20 | 6d 69 63 72 6f 63 69 72 |mproves |microcir|
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|00000bd0| 64 20 74 69 73 73 75 65 | 20 6f 78 79 67 65 6e 61 |d tissue| oxygena|
|00000be0| 74 69 6f 6e 0d 0a 70 6f | 73 73 69 62 6c 79 20 62 |tion..po|ssibly b|
|00000bf0| 79 20 69 6e 63 72 65 61 | 73 69 6e 67 20 65 72 79 |y increa|sing ery|
|00000c00| 74 68 72 6f 63 79 74 65 | 20 64 65 66 6f 72 6d 61 |throcyte| deforma|
|00000c10| 62 69 6c 69 74 79 20 62 | 79 20 72 61 69 73 69 6e |bility b|y raisin|
|00000c20| 67 20 74 68 65 20 61 64 | 65 6e 6f 73 69 6e 65 0d |g the ad|enosine.|
|00000c30| 0a 74 72 69 70 68 6f 73 | 70 68 61 74 65 20 63 6f |.triphos|phate co|
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|00000c60| 67 61 74 69 6f 6e 2c 20 | 61 6e 64 20 72 65 64 75 |gation, |and redu|
|00000c70| 63 69 6e 67 20 70 6c 61 | 73 6d 61 0d 0a 66 69 62 |cing pla|sma..fib|
|00000c80| 72 69 6e 6f 67 65 6e 20 | 63 6f 6e 63 65 6e 74 72 |rinogen |concentr|
|00000c90| 61 74 69 6f 6e 73 2e 20 | 20 54 68 65 20 65 66 66 |ations. | The eff|
|00000ca0| 69 63 61 63 79 20 61 6e | 64 20 73 61 66 65 74 79 |icacy an|d safety|
|00000cb0| 20 6f 66 20 50 54 58 20 | 77 65 72 65 20 61 73 73 | of PTX |were ass|
|00000cc0| 65 73 73 65 64 20 69 6e | 20 61 0d 0a 6d 75 6c 74 |essed in| a..mult|
|00000cd0| 69 63 65 6e 74 65 72 2c | 20 64 6f 75 62 6c 65 2d |icenter,| double-|
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|00000d00| 6f 6e 74 72 6f 6c 6c 65 | 64 20 74 72 69 61 6c 20 |ontrolle|d trial |
|00000d10| 69 6e 76 6f 6c 76 69 6e | 67 0d 0a 32 39 37 20 61 |involvin|g..297 a|
|00000d20| 64 75 6c 74 73 20 77 69 | 74 68 20 61 63 75 74 65 |dults wi|th acute|
|00000d30| 20 69 73 63 68 65 6d 69 | 63 20 73 74 72 6f 6b 65 | ischemi|c stroke|
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|00001790| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000017a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000017b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000017c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 43 61 6c 66 |--------|--..Calf|
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|000018b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00002350| 56 6f 6c 75 6d 65 7b 32 | 7d 0d 0a 24 50 61 67 65 |Volume{2|}..$Page|
|00002360| 7b 34 39 37 2d 34 39 38 | 7d 0d 0a 24 44 61 74 65 |{497-498|}..$Date|
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|00002620| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00002b10| 6e 74 20 64 65 68 79 64 | 72 61 74 69 6f 6e 2e 20 |nt dehyd|ration. |
|00002b20| 20 50 65 72 73 6f 6e 73 | 20 61 74 20 72 69 73 6b | Persons| at risk|
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|00002b40| 72 20 74 61 6b 69 6e 67 | 20 6c 6f 77 2d 64 6f 73 |r taking| low-dos|
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|00002c50| 72 65 61 74 65 72 20 69 | 6d 70 6f 72 74 61 6e 63 |reater i|mportanc|
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|00002cf0| 70 72 6f 76 69 64 65 20 | 61 64 65 71 75 61 74 65 |provide |adequate|
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|00002d50| 6e 20 69 6e 76 65 6e 74 | 69 6f 6e 20 6f 66 20 74 |n invent|ion of t|
|00002d60| 68 65 20 64 65 76 69 6c | 2e 22 0d 0a 20 20 20 20 |he devil|.".. |
|00002d70| 20 43 69 67 61 72 65 74 | 74 65 20 73 6d 6f 6b 65 | Cigaret|te smoke|
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|00002db0| 0d 0a 69 6e 63 72 65 61 | 73 69 6e 67 20 62 6c 6f |..increa|sing blo|
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|00002dd0| 68 69 73 20 69 73 20 61 | 20 67 6f 6f 64 20 72 65 |his is a| good re|
|00002de0| 61 73 6f 6e 20 74 6f 20 | 70 75 73 68 20 66 6f 72 |ason to |push for|
|00002df0| 20 61 20 6e 6f 2d 73 6d | 6f 6b 69 6e 67 0d 0a 70 | a no-sm|oking..p|
|00002e00| 6f 6c 69 63 79 20 6f 6e | 20 61 6c 6c 20 66 6c 69 |olicy on| all fli|
|00002e10| 67 68 74 73 2e 2d 2d 52 | 2e 45 2e 20 52 61 6b 65 |ghts.--R|.E. Rake|
|00002e20| 6c 2c 20 4d 2e 44 2e 0d | 0a 24 55 6e 69 71 75 65 |l, M.D..|.$Unique|
|00002e30| 5f 49 44 7b 59 52 42 31 | 30 37 30 33 7d 0d 0a 24 |_ID{YRB1|0703}..$|
|00002e40| 54 69 74 6c 65 7b 50 65 | 6e 74 6f 78 69 66 79 6c |Title{Pe|ntoxifyl|
|00002e50| 6c 69 6e 65 20 49 6e 63 | 72 65 61 73 65 73 20 45 |line Inc|reases E|
|00002e60| 78 74 72 65 6d 69 74 79 | 20 42 6c 6f 6f 64 20 46 |xtremity| Blood F|
|00002e70| 6c 6f 77 20 69 6e 20 44 | 69 61 62 65 74 69 63 20 |low in D|iabetic |
|00002e80| 41 74 68 65 72 6f 73 63 | 6c 65 72 6f 74 69 63 20 |Atherosc|lerotic |
|00002e90| 50 61 74 69 65 6e 74 73 | 7d 0d 0a 24 41 75 74 68 |Patients|}..$Auth|
|00002ea0| 6f 72 7b 53 63 68 77 61 | 72 74 7a 2c 20 52 57 0d |or{Schwa|rtz, RW.|
|00002eb0| 0a 4c 6f 67 61 6e 2c 20 | 4e 4d 0d 0a 4a 6f 68 6e |.Logan, |NM..John|
|00002ec0| 73 6f 6e 2c 20 50 4a 0d | 0a 53 74 72 6f 64 65 6c |son, PJ.|.Strodel|
|00002ed0| 2c 20 57 45 0d 0a 46 69 | 6e 65 2c 20 4a 47 0d 0a |, WE..Fi|ne, JG..|
|00002ee0| 4b 61 7a 6d 65 72 73 2c | 20 41 0d 0a 48 79 64 65 |Kazmers,| A..Hyde|
|00002ef0| 2c 20 47 4c 7d 0d 0a 24 | 41 66 66 69 6c 69 61 74 |, GL}..$|Affiliat|
|00002f00| 69 6f 6e 7b 55 6e 69 76 | 20 6f 66 20 4b 65 6e 74 |ion{Univ| of Kent|
|00002f10| 75 63 6b 79 7d 0d 0a 24 | 4a 6f 75 72 6e 61 6c 7b |ucky}..$|Journal{|
|00002f20| 41 72 63 68 20 53 75 72 | 67 7d 0d 0a 24 56 6f 6c |Arch Sur|g}..$Vol|
|00002f30| 75 6d 65 7b 31 32 34 7d | 0d 0a 24 50 61 67 65 7b |ume{124}|..$Page{|
|00002f40| 34 33 34 2d 34 33 37 7d | 0d 0a 24 44 61 74 65 7b |434-437}|..$Date{|
|00002f50| 41 70 72 69 6c 20 31 39 | 38 39 7d 0d 0a 24 59 42 |April 19|89}..$YB|
|00002f60| 56 6f 6c 7b 31 39 39 30 | 20 59 65 61 72 20 42 6f |Vol{1990| Year Bo|
|00002f70| 6f 6b 20 6f 66 20 46 61 | 6d 69 6c 79 20 50 72 61 |ok of Fa|mily Pra|
|00002f80| 63 74 69 63 65 7d 0d 0a | 24 43 68 61 70 74 65 72 |ctice}..|$Chapter|
|00002f90| 7b 38 2d 36 34 7d 0d 0a | 24 59 42 45 64 69 74 6f |{8-64}..|$YBEdito|
|00002fa0| 72 7b 44 72 73 2e 20 52 | 61 6b 65 6c 2c 20 41 76 |r{Drs. R|akel, Av|
|00002fb0| 61 6e 74 2c 20 44 72 69 | 73 63 6f 6c 6c 2c 20 50 |ant, Dri|scoll, P|
|00002fc0| 72 69 63 68 61 72 64 2c | 20 61 6e 64 20 53 6d 69 |richard,| and Smi|
|00002fd0| 74 68 7d 0d 0a 24 54 61 | 62 6c 65 7b 7d 0d 0a 24 |th}..$Ta|ble{}..$|
|00002fe0| 43 6f 6d 6d 65 6e 74 61 | 74 6f 72 7b 52 2e 45 2e |Commenta|tor{R.E.|
|00002ff0| 20 52 61 6b 65 6c 2c 20 | 4d 2e 44 2e 7d 0d 0a 0d | Rakel, |M.D.}...|
|00003000| 0a 43 6f 70 79 72 69 67 | 68 74 20 28 63 29 20 59 |.Copyrig|ht (c) Y|
|00003010| 65 61 72 62 6f 6f 6b 20 | 4d 65 64 69 63 61 6c 20 |earbook |Medical |
|00003020| 50 75 62 6c 69 73 68 65 | 72 73 2c 20 49 6e 63 2e |Publishe|rs, Inc.|
|00003030| 2c 20 31 39 39 30 0d 0a | 0d 0a 31 39 39 30 20 59 |, 1990..|..1990 Y|
|00003040| 65 61 72 20 42 6f 6f 6b | 20 6f 66 20 46 61 6d 69 |ear Book| of Fami|
|00003050| 6c 79 20 50 72 61 63 74 | 69 63 65 20 28 52 29 0d |ly Pract|ice (R).|
|00003060| 0a 0d 0a 43 68 61 70 74 | 65 72 20 38 2d 2d 44 69 |...Chapt|er 8--Di|
|00003070| 73 65 61 73 65 73 20 6f | 66 20 74 68 65 20 43 69 |seases o|f the Ci|
|00003080| 72 63 75 6c 61 74 6f 72 | 79 20 53 79 73 74 65 6d |rculator|y System|
|00003090| 0d 0a 0d 0a 50 65 72 69 | 70 65 72 61 6c 20 56 61 |....Peri|peral Va|
|000030a0| 73 63 75 6c 61 72 20 44 | 69 73 6f 72 64 65 72 73 |scular D|isorders|
|000030b0| 0d 0a 0d 0a 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |....----|--------|
|000030c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000030d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000030e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000030f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003100| 2d 2d 0d 0a 50 65 6e 74 | 6f 78 69 66 79 6c 6c 69 |--..Pent|oxifylli|
|00003110| 6e 65 20 49 6e 63 72 65 | 61 73 65 73 20 45 78 74 |ne Incre|ases Ext|
|00003120| 72 65 6d 69 74 79 20 42 | 6c 6f 6f 64 20 46 6c 6f |remity B|lood Flo|
|00003130| 77 20 69 6e 20 44 69 61 | 62 65 74 69 63 20 41 74 |w in Dia|betic At|
|00003140| 68 65 72 6f 73 63 6c 65 | 72 6f 74 69 63 0d 0a 50 |heroscle|rotic..P|
|00003150| 61 74 69 65 6e 74 73 0d | 0a 0d 0a 53 63 68 77 61 |atients.|...Schwa|
|00003160| 72 74 7a 20 52 57 3b 20 | 4c 6f 67 61 6e 20 4e 4d |rtz RW; |Logan NM|
|00003170| 3b 20 4a 6f 68 6e 73 6f | 6e 20 50 4a 3b 20 53 74 |; Johnso|n PJ; St|
|00003180| 72 6f 64 65 6c 20 57 45 | 3b 20 46 69 6e 65 20 4a |rodel WE|; Fine J|
|00003190| 47 3b 20 4b 61 7a 6d 65 | 72 73 20 41 3b 20 48 79 |G; Kazme|rs A; Hy|
|000031a0| 64 65 20 47 4c 0d 0a 28 | 55 6e 69 76 20 6f 66 20 |de GL..(|Univ of |
|000031b0| 4b 65 6e 74 75 63 6b 79 | 29 0d 0a 41 72 63 68 20 |Kentucky|)..Arch |
|000031c0| 53 75 72 67 20 31 32 34 | 3a 34 33 34 2d 34 33 37 |Surg 124|:434-437|
|000031d0| 2c 20 41 70 72 69 6c 20 | 31 39 38 39 0d 0a 2d 2d |, April |1989..--|
|000031e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000031f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003200| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003210| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003220| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 0d 0a |--------|----....|
|00003230| 41 62 73 74 72 61 63 74 | 0d 0a 0d 0a 20 20 20 20 |Abstract|.... |
|00003240| 20 50 65 6e 74 6f 78 69 | 66 79 6c 6c 69 6e 65 20 | Pentoxi|fylline |
|00003250| 28 50 54 58 29 20 72 65 | 70 6f 72 74 65 64 6c 79 |(PTX) re|portedly|
|00003260| 20 69 6d 70 72 6f 76 65 | 73 20 68 65 6d 6f 72 72 | improve|s hemorr|
|00003270| 68 65 6f 6c 6f 67 69 63 | 20 66 6c 6f 77 0d 0a 63 |heologic| flow..c|
|00003280| 68 61 72 61 63 74 65 72 | 69 73 74 69 63 73 20 61 |haracter|istics a|
|00003290| 6e 64 20 73 68 6f 75 6c | 64 20 6c 6f 77 65 72 20 |nd shoul|d lower |
|000032a0| 70 65 72 69 70 68 65 72 | 61 6c 20 76 61 73 63 75 |peripher|al vascu|
|000032b0| 6c 61 72 20 72 65 73 69 | 73 74 61 6e 63 65 20 61 |lar resi|stance a|
|000032c0| 6e 64 20 65 6e 68 61 6e | 63 65 0d 0a 70 65 72 69 |nd enhan|ce..peri|
|000032d0| 70 68 65 72 61 6c 20 74 | 69 73 73 75 65 20 62 6c |pheral t|issue bl|
|000032e0| 6f 6f 64 20 66 6c 6f 77 | 2e 20 20 48 6f 77 65 76 |ood flow|. Howev|
|000032f0| 65 72 2c 20 73 6f 6d 65 | 20 73 74 75 64 69 65 73 |er, some| studies|
|00003300| 20 68 61 76 65 20 66 61 | 69 6c 65 64 20 74 6f 20 | have fa|iled to |
|00003310| 69 6e 64 69 63 61 74 65 | 0d 0a 63 6c 69 6e 69 63 |indicate|..clinic|
|00003320| 61 6c 6c 79 20 75 73 65 | 66 75 6c 20 65 66 66 65 |ally use|ful effe|
|00003330| 63 74 73 20 6f 66 20 74 | 68 65 20 64 72 75 67 2e |cts of t|he drug.|
|00003340| 20 20 41 6e 20 61 74 74 | 65 6d 70 74 20 77 61 73 | An att|empt was|
|00003350| 20 6d 61 64 65 20 74 6f | 20 71 75 61 6e 74 69 66 | made to| quantif|
|00003360| 79 20 74 68 65 0d 0a 63 | 69 72 63 75 6c 61 74 6f |y the..c|irculato|
|00003370| 72 79 20 65 66 66 65 63 | 74 73 20 6f 66 20 50 54 |ry effec|ts of PT|
|00003380| 58 20 62 79 20 44 6f 70 | 70 6c 65 72 20 77 61 76 |X by Dop|pler wav|
|00003390| 65 66 6f 72 6d 20 61 6e | 61 6c 79 73 69 73 20 69 |eform an|alysis i|
|000033a0| 6e 20 31 30 20 70 61 74 | 69 65 6e 74 73 20 77 69 |n 10 pat|ients wi|
|000033b0| 74 68 0d 0a 63 68 72 6f | 6e 69 63 20 6f 63 63 6c |th..chro|nic occl|
|000033c0| 75 73 69 76 65 20 61 72 | 74 65 72 69 61 6c 20 64 |usive ar|terial d|
|000033d0| 69 73 65 61 73 65 20 61 | 6e 64 20 73 74 61 62 6c |isease a|nd stabl|
|000033e0| 65 20 69 6e 74 65 72 6d | 69 74 74 65 6e 74 20 63 |e interm|ittent c|
|000033f0| 6c 61 75 64 69 63 61 74 | 69 6f 6e 2e 20 20 54 68 |laudicat|ion. Th|
|00003400| 65 0d 0a 70 61 74 69 65 | 6e 74 73 2c 20 61 6c 6c |e..patie|nts, all|
|00003410| 20 64 69 61 62 65 74 69 | 63 73 2c 20 64 69 64 20 | diabeti|cs, did |
|00003420| 6e 6f 74 20 68 61 76 65 | 20 6c 6f 77 65 72 20 6c |not have| lower l|
|00003430| 69 6d 62 20 75 6c 63 65 | 72 61 74 69 6f 6e 20 6f |imb ulce|ration o|
|00003440| 72 20 67 61 6e 67 72 65 | 6e 65 2e 0d 0a 20 20 20 |r gangre|ne... |
|00003450| 20 20 45 78 65 72 63 69 | 73 65 20 74 6f 6c 65 72 | Exerci|se toler|
|00003460| 61 6e 63 65 20 69 6d 70 | 72 6f 76 65 64 20 73 69 |ance imp|roved si|
|00003470| 67 6e 69 66 69 63 61 6e | 74 6c 79 20 64 75 72 69 |gnifican|tly duri|
|00003480| 6e 67 20 74 72 65 61 74 | 6d 65 6e 74 20 77 69 74 |ng treat|ment wit|
|00003490| 68 20 34 30 30 20 6d 67 | 20 6f 66 0d 0a 50 54 58 |h 400 mg| of..PTX|
|000034a0| 20 33 20 74 69 6d 65 73 | 20 64 61 69 6c 79 20 66 | 3 times| daily f|
|000034b0| 6f 72 20 31 32 20 77 65 | 65 6b 73 2e 20 20 44 6f |or 12 we|eks. Do|
|000034c0| 72 73 61 6c 69 73 20 70 | 65 64 69 73 20 70 72 65 |rsalis p|edis pre|
|000034d0| 73 73 75 72 65 73 20 64 | 69 64 20 6e 6f 74 20 63 |ssures d|id not c|
|000034e0| 68 61 6e 67 65 0d 0a 73 | 69 67 6e 69 66 69 63 61 |hange..s|ignifica|
|000034f0| 6e 74 6c 79 2e 20 20 54 | 68 65 20 44 6f 70 70 6c |ntly. T|he Doppl|
|00003500| 65 72 20 77 61 76 65 66 | 6f 72 6d 20 69 6d 70 72 |er wavef|orm impr|
|00003510| 6f 76 65 64 20 69 6e 20 | 61 6c 6c 20 62 75 74 20 |oved in |all but |
|00003520| 31 20 70 61 74 69 65 6e | 74 2c 20 77 68 6f 20 77 |1 patien|t, who w|
|00003530| 61 73 0d 0a 6f 6e 6c 79 | 20 6d 61 72 67 69 6e 61 |as..only| margina|
|00003540| 6c 6c 79 20 63 6f 6d 70 | 6c 69 61 6e 74 20 77 69 |lly comp|liant wi|
|00003550| 74 68 20 74 72 65 61 74 | 6d 65 6e 74 2e 20 20 54 |th treat|ment. T|
|00003560| 68 65 20 6d 65 61 6e 20 | 64 6f 72 73 61 6c 69 73 |he mean |dorsalis|
|00003570| 20 70 65 64 69 73 20 77 | 61 76 65 66 6f 72 6d 0d | pedis w|aveform.|
|00003580| 0a 69 6e 63 72 65 61 73 | 65 64 20 66 72 6f 6d 20 |.increas|ed from |
|00003590| 32 30 36 20 63 6d 20 74 | 6f 20 33 37 32 20 63 6d |206 cm t|o 372 cm|
|000035a0| 2e 0d 0a 20 20 20 20 20 | 54 68 65 20 6d 65 61 6e |... |The mean|
|000035b0| 73 20 62 79 20 77 68 69 | 63 68 20 50 54 58 20 65 |s by whi|ch PTX e|
|000035c0| 78 65 72 74 73 20 69 74 | 73 20 70 6f 73 69 74 69 |xerts it|s positi|
|000035d0| 76 65 20 65 66 66 65 63 | 74 73 20 6f 6e 20 62 6c |ve effec|ts on bl|
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|00005100| 6e 74 69 6c 20 72 75 70 | 74 75 72 65 20 6f 63 63 |ntil rup|ture occ|
|00005110| 75 72 73 2c 20 61 6e 64 | 20 74 68 65 6e 20 74 68 |urs, and| then th|
|00005120| 65 20 6d 6f 72 74 61 6c | 69 74 79 0d 0a 72 61 74 |e mortal|ity..rat|
|00005130| 65 20 69 73 20 35 30 25 | 20 74 6f 20 38 30 25 2e |e is 50%| to 80%.|
|00005140| 2d 2d 52 2e 45 2e 20 52 | 61 6b 65 6c 2c 20 4d 2e |--R.E. R|akel, M.|
|00005150| 44 2e 0d 0a 24 55 6e 69 | 71 75 65 5f 49 44 7b 59 |D...$Uni|que_ID{Y|
|00005160| 52 42 31 30 37 30 36 7d | 0d 0a 24 54 69 74 6c 65 |RB10706}|..$Title|
|00005170| 7b 54 65 6c 61 6e 67 69 | 65 63 74 61 73 69 61 20 |{Telangi|ectasia |
|00005180| 61 6e 64 20 53 63 6c 65 | 72 6f 74 68 65 72 61 70 |and Scle|rotherap|
|00005190| 79 7d 0d 0a 24 41 75 74 | 68 6f 72 7b 4f 75 76 72 |y}..$Aut|hor{Ouvr|
|000051a0| 79 2c 20 50 41 7d 0d 0a | 24 41 66 66 69 6c 69 61 |y, PA}..|$Affilia|
|000051b0| 74 69 6f 6e 7b 43 6c 69 | 6e 69 71 75 65 20 53 61 |tion{Cli|nique Sa|
|000051c0| 69 6e 74 2d 50 69 65 72 | 72 65 2c 20 44 69 65 70 |int-Pier|re, Diep|
|000051d0| 70 65 2c 20 46 72 61 6e | 63 65 7d 0d 0a 24 4a 6f |pe, Fran|ce}..$Jo|
|000051e0| 75 72 6e 61 6c 7b 4a 20 | 44 65 72 6d 61 74 6f 6c |urnal{J |Dermatol|
|000051f0| 20 53 75 72 67 20 4f 6e | 63 6f 6c 7d 0d 0a 24 56 | Surg On|col}..$V|
|00005200| 6f 6c 75 6d 65 7b 31 35 | 7d 0d 0a 24 50 61 67 65 |olume{15|}..$Page|
|00005210| 7b 31 37 37 2d 31 38 31 | 7d 0d 0a 24 44 61 74 65 |{177-181|}..$Date|
|00005220| 7b 46 65 62 72 75 61 72 | 79 20 31 39 38 39 7d 0d |{Februar|y 1989}.|
|00005230| 0a 24 59 42 56 6f 6c 7b | 31 39 39 30 20 59 65 61 |.$YBVol{|1990 Yea|
|00005240| 72 20 42 6f 6f 6b 20 6f | 66 20 46 61 6d 69 6c 79 |r Book o|f Family|
|00005250| 20 50 72 61 63 74 69 63 | 65 7d 0d 0a 24 43 68 61 | Practic|e}..$Cha|
|00005260| 70 74 65 72 7b 38 2d 36 | 37 7d 0d 0a 24 59 42 45 |pter{8-6|7}..$YBE|
|00005270| 64 69 74 6f 72 7b 44 72 | 73 2e 20 52 61 6b 65 6c |ditor{Dr|s. Rakel|
|00005280| 2c 20 41 76 61 6e 74 2c | 20 44 72 69 73 63 6f 6c |, Avant,| Driscol|
|00005290| 6c 2c 20 50 72 69 63 68 | 61 72 64 2c 20 61 6e 64 |l, Prich|ard, and|
|000052a0| 20 53 6d 69 74 68 7d 0d | 0a 24 54 61 62 6c 65 7b | Smith}.|.$Table{|
|000052b0| 7d 0d 0a 24 43 6f 6d 6d | 65 6e 74 61 74 6f 72 7b |}..$Comm|entator{|
|000052c0| 52 2e 45 2e 20 52 61 6b | 65 6c 2c 20 4d 2e 44 2e |R.E. Rak|el, M.D.|
|000052d0| 7d 0d 0a 0d 0a 43 6f 70 | 79 72 69 67 68 74 20 28 |}....Cop|yright (|
|000052e0| 63 29 20 59 65 61 72 62 | 6f 6f 6b 20 4d 65 64 69 |c) Yearb|ook Medi|
|000052f0| 63 61 6c 20 50 75 62 6c | 69 73 68 65 72 73 2c 20 |cal Publ|ishers, |
|00005300| 49 6e 63 2e 2c 20 31 39 | 39 30 0d 0a 0d 0a 31 39 |Inc., 19|90....19|
|00005310| 39 30 20 59 65 61 72 20 | 42 6f 6f 6b 20 6f 66 20 |90 Year |Book of |
|00005320| 46 61 6d 69 6c 79 20 50 | 72 61 63 74 69 63 65 20 |Family P|ractice |
|00005330| 28 52 29 0d 0a 0d 0a 43 | 68 61 70 74 65 72 20 38 |(R)....C|hapter 8|
|00005340| 2d 2d 44 69 73 65 61 73 | 65 73 20 6f 66 20 74 68 |--Diseas|es of th|
|00005350| 65 20 43 69 72 63 75 6c | 61 74 6f 72 79 20 53 79 |e Circul|atory Sy|
|00005360| 73 74 65 6d 0d 0a 0d 0a | 50 65 72 69 70 68 65 72 |stem....|Peripher|
|00005370| 61 6c 20 56 61 73 63 75 | 6c 61 72 20 44 69 73 6f |al Vascu|lar Diso|
|00005380| 72 64 65 72 73 0d 0a 0d | 0a 2d 2d 2d 2d 2d 2d 2d |rders...|.-------|
|00005390| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000053a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000053b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000053c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000053d0| 2d 2d 2d 2d 2d 2d 2d 0d | 0a 54 65 6c 61 6e 67 69 |-------.|.Telangi|
|000053e0| 65 63 74 61 73 69 61 20 | 61 6e 64 20 53 63 6c 65 |ectasia |and Scle|
|000053f0| 72 6f 74 68 65 72 61 70 | 79 0d 0a 0d 0a 4f 75 76 |rotherap|y....Ouv|
|00005400| 72 79 20 50 41 0d 0a 28 | 43 6c 69 6e 69 71 75 65 |ry PA..(|Clinique|
|00005410| 20 53 61 69 6e 74 2d 50 | 69 65 72 72 65 2c 20 44 | Saint-P|ierre, D|
|00005420| 69 65 70 70 65 2c 20 46 | 72 61 6e 63 65 29 0d 0a |ieppe, F|rance)..|
|00005430| 4a 20 44 65 72 6d 61 74 | 6f 6c 20 53 75 72 67 20 |J Dermat|ol Surg |
|00005440| 4f 6e 63 6f 6c 20 31 35 | 3a 31 37 37 2d 31 38 31 |Oncol 15|:177-181|
|00005450| 2c 20 46 65 62 72 75 61 | 72 79 20 31 39 38 39 0d |, Februa|ry 1989.|
|00005460| 0a 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |.-------|--------|
|00005470| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005480| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005490| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000054a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 0d |--------|-------.|
|000054b0| 0a 0d 0a 41 62 73 74 72 | 61 63 74 0d 0a 0d 0a 20 |...Abstr|act.... |
|000054c0| 20 20 20 20 41 20 72 65 | 76 69 65 77 20 77 61 73 | A re|view was|
|000054d0| 20 6d 61 64 65 20 6f 66 | 20 74 68 65 20 61 6e 61 | made of| the ana|
|000054e0| 74 6f 6d 79 2c 20 70 68 | 79 73 69 6f 6c 6f 67 79 |tomy, ph|ysiology|
|000054f0| 2c 20 61 6e 64 20 65 74 | 69 6f 6c 6f 67 79 20 6f |, and et|iology o|
|00005500| 66 0d 0a 74 65 6c 61 6e | 67 69 65 63 74 61 73 69 |f..telan|giectasi|
|00005510| 61 2c 20 61 73 20 77 65 | 6c 6c 20 61 73 20 69 74 |a, as we|ll as it|
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|00005540| 65 6c 61 6e 67 69 65 63 | 74 61 73 69 61 20 61 72 |elangiec|tasia ar|
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|00005570| 20 69 6e 20 74 68 65 20 | 73 75 70 65 72 66 69 63 | in the |superfic|
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|00005660| 2e 20 20 4f 74 68 65 72 | 20 66 61 63 74 6f 72 73 |. Other| factors|
|00005670| 20 73 75 63 68 20 61 73 | 0d 0a 74 69 67 68 74 20 | such as|..tight |
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|00005690| 69 6e 67 2c 20 74 79 69 | 6e 67 20 6f 66 66 2c 20 |ing, tyi|ng off, |
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|00005b00| 63 6c 65 72 6f 6d 61 74 | 65 29 2c 20 73 6f 64 69 |cleromat|e), sodi|
|00005b10| 75 6d 20 74 65 74 72 61 | 64 65 63 79 6c 20 28 53 |um tetra|decyl (S|
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|00005b40| 61 6e 6f 6c 61 6d 69 6e | 65 20 6f 6c 65 61 74 65 |anolamin|e oleate|
|00005b50| 20 28 45 74 68 61 6d 6f | 6c 69 6e 29 2e 20 20 41 | (Ethamo|lin). A|
|00005b60| 6e 20 65 6c 61 73 74 69 | 63 20 70 72 65 73 73 75 |n elasti|c pressu|
|00005b70| 72 65 20 62 61 6e 64 61 | 67 65 20 6f 72 20 70 72 |re banda|ge or pr|
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|00005bd0| 72 73 20 61 74 0d 0a 74 | 68 65 20 69 6e 6a 65 63 |rs at..t|he injec|
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|00005c20| 68 65 72 65 0d 0a 69 73 | 20 69 6e 73 75 66 66 69 |here..is| insuffi|
|00005c30| 63 69 65 6e 63 79 20 6f | 66 20 74 68 65 20 73 68 |ciency o|f the sh|
|00005c40| 6f 72 74 20 73 61 70 68 | 65 6e 6f 75 73 20 76 65 |ort saph|enous ve|
|00005c50| 69 6e 73 2e 2d 2d 52 2e | 45 2e 20 52 61 6b 65 6c |ins.--R.|E. Rakel|
|00005c60| 2c 20 4d 2e 44 2e 0d 0a | 24 55 6e 69 71 75 65 5f |, M.D...|$Unique_|
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|00005ca0| 69 6e 67 20 56 61 73 63 | 75 6c 69 74 69 73 7d 0d |ing Vasc|ulitis}.|
|00005cb0| 0a 24 41 75 74 68 6f 72 | 7b 43 6f 6e 6e 2c 20 44 |.$Author|{Conn, D|
|00005cc0| 4c 7d 0d 0a 24 41 66 66 | 69 6c 69 61 74 69 6f 6e |L}..$Aff|iliation|
|00005cd0| 7b 4d 61 79 6f 20 43 6c | 69 6e 69 63 20 61 6e 64 |{Mayo Cl|inic and|
|00005ce0| 20 46 6f 75 6e 64 2c 20 | 52 6f 63 68 65 73 74 65 | Found, |Rocheste|
|00005cf0| 72 2c 20 4d 69 6e 6e 7d | 0d 0a 24 4a 6f 75 72 6e |r, Minn}|..$Journ|
|00005d00| 61 6c 7b 4d 61 79 6f 20 | 43 6c 69 6e 20 50 72 6f |al{Mayo |Clin Pro|
|00005d10| 63 7d 0d 0a 24 56 6f 6c | 75 6d 65 7b 36 34 7d 0d |c}..$Vol|ume{64}.|
|00005d20| 0a 24 50 61 67 65 7b 35 | 33 35 2d 35 34 33 7d 0d |.$Page{5|35-543}.|
|00005d30| 0a 24 44 61 74 65 7b 4d | 61 79 20 31 39 38 39 7d |.$Date{M|ay 1989}|
|00005d40| 0d 0a 24 59 42 56 6f 6c | 7b 31 39 39 30 20 59 65 |..$YBVol|{1990 Ye|
|00005d50| 61 72 20 42 6f 6f 6b 20 | 6f 66 20 46 61 6d 69 6c |ar Book |of Famil|
|00005d60| 79 20 50 72 61 63 74 69 | 63 65 7d 0d 0a 24 43 68 |y Practi|ce}..$Ch|
|00005d70| 61 70 74 65 72 7b 38 2d | 36 38 7d 0d 0a 24 59 42 |apter{8-|68}..$YB|
|00005d80| 45 64 69 74 6f 72 7b 44 | 72 73 2e 20 52 61 6b 65 |Editor{D|rs. Rake|
|00005d90| 6c 2c 20 41 76 61 6e 74 | 2c 20 44 72 69 73 63 6f |l, Avant|, Drisco|
|00005da0| 6c 6c 2c 20 50 72 69 63 | 68 61 72 64 2c 20 61 6e |ll, Pric|hard, an|
|00005db0| 64 20 53 6d 69 74 68 7d | 0d 0a 24 54 61 62 6c 65 |d Smith}|..$Table|
|00005dc0| 7b 54 61 62 6c 65 20 4f | 6d 69 74 74 65 64 7d 0d |{Table O|mitted}.|
|00005dd0| 0a 24 43 6f 6d 6d 65 6e | 74 61 74 6f 72 7b 52 2e |.$Commen|tator{R.|
|00005de0| 45 2e 20 52 61 6b 65 6c | 2c 20 4d 2e 44 2e 7d 0d |E. Rakel|, M.D.}.|
|00005df0| 0a 0d 0a 43 6f 70 79 72 | 69 67 68 74 20 28 63 29 |...Copyr|ight (c)|
|00005e00| 20 59 65 61 72 62 6f 6f | 6b 20 4d 65 64 69 63 61 | Yearboo|k Medica|
|00005e10| 6c 20 50 75 62 6c 69 73 | 68 65 72 73 2c 20 49 6e |l Publis|hers, In|
|00005e20| 63 2e 2c 20 31 39 39 30 | 0d 0a 0d 0a 31 39 39 30 |c., 1990|....1990|
|00005e30| 20 59 65 61 72 20 42 6f | 6f 6b 20 6f 66 20 46 61 | Year Bo|ok of Fa|
|00005e40| 6d 69 6c 79 20 50 72 61 | 63 74 69 63 65 20 28 52 |mily Pra|ctice (R|
|00005e50| 29 0d 0a 0d 0a 43 68 61 | 70 74 65 72 20 38 2d 2d |)....Cha|pter 8--|
|00005e60| 44 69 73 65 61 73 65 73 | 20 6f 66 20 74 68 65 20 |Diseases| of the |
|00005e70| 43 69 72 63 75 6c 61 74 | 6f 72 79 20 53 79 73 74 |Circulat|ory Syst|
|00005e80| 65 6d 0d 0a 0d 0a 4d 69 | 73 63 65 6c 6c 61 6e 65 |em....Mi|scellane|
|00005e90| 6f 75 73 0d 0a 0d 0a 2d | 2d 2d 2d 2d 2d 2d 2d 2d |ous....-|--------|
|00005ea0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005eb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005ec0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005ed0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005ee0| 2d 2d 2d 2d 2d 0d 0a 55 | 70 64 61 74 65 20 6f 6e |-----..U|pdate on|
|00005ef0| 20 53 79 73 74 65 6d 69 | 63 20 4e 65 63 72 6f 74 | Systemi|c Necrot|
|00005f00| 69 7a 69 6e 67 20 56 61 | 73 63 75 6c 69 74 69 73 |izing Va|sculitis|
|00005f10| 0d 0a 0d 0a 43 6f 6e 6e | 20 44 4c 0d 0a 28 4d 61 |....Conn| DL..(Ma|
|00005f20| 79 6f 20 43 6c 69 6e 69 | 63 20 61 6e 64 20 46 6f |yo Clini|c and Fo|
|00005f30| 75 6e 64 2c 20 52 6f 63 | 68 65 73 74 65 72 2c 20 |und, Roc|hester, |
|00005f40| 4d 69 6e 6e 29 0d 0a 4d | 61 79 6f 20 43 6c 69 6e |Minn)..M|ayo Clin|
|00005f50| 20 50 72 6f 63 20 36 34 | 3a 35 33 35 2d 35 34 33 | Proc 64|:535-543|
|00005f60| 2c 20 4d 61 79 20 31 39 | 38 39 0d 0a 2d 2d 2d 2d |, May 19|89..----|
|00005f70| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005f80| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005f90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005fa0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005fb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 0d 0a 41 62 |--------|--....Ab|
|00005fc0| 73 74 72 61 63 74 0d 0a | 0d 0a 20 20 20 20 20 54 |stract..|.. T|
|00005fd0| 68 65 20 63 6f 6e 64 69 | 74 69 6f 6e 73 20 74 68 |he condi|tions th|
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|00005ff0| 65 6d 69 63 20 6e 65 63 | 72 6f 74 69 7a 69 6e 67 |emic nec|rotizing|
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|00006010| 0a 63 68 61 72 61 63 74 | 65 72 69 7a 65 64 20 70 |.charact|erized p|
|00006020| 61 74 68 6f 6c 6f 67 69 | 63 61 6c 6c 79 20 62 79 |athologi|cally by|
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|00006040| 20 74 68 65 20 62 6c 6f | 6f 64 20 76 65 73 73 65 | the blo|od vesse|
|00006050| 6c 73 2e 20 20 53 79 73 | 74 65 6d 69 63 0d 0a 76 |ls. Sys|temic..v|
|00006060| 61 73 63 75 6c 69 74 69 | 73 20 68 61 73 20 61 20 |asculiti|s has a |
|00006070| 6e 75 6d 62 65 72 20 6f | 66 20 63 6f 6d 6d 6f 6e |number o|f common|
|00006080| 20 70 61 74 74 65 72 6e | 73 2c 20 69 6e 63 6c 75 | pattern|s, inclu|
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|000060b0| 73 2c 20 70 6f 6c 79 61 | 72 74 65 72 69 74 69 73 |s, polya|rteritis|
|000060c0| 2c 20 43 68 75 72 67 2d | 53 74 72 61 75 73 73 20 |, Churg-|Strauss |
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|00006110| 69 61 6e 74 20 63 65 6c | 6c 20 61 72 74 65 72 69 |iant cel|l arteri|
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|00006140| 0a 61 72 74 65 72 69 74 | 69 73 20 69 73 20 75 73 |.arterit|is is us|
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|00006180| 69 73 6d 20 69 73 0d 0a | 67 65 6e 65 72 61 6c 6c |ism is..|generall|
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|000061e0| 6e 64 20 68 65 72 70 65 | 73 20 7a 6f 73 74 65 72 |nd herpe|s zoster|
|000061f0| 29 20 6d 61 79 20 61 6c | 73 6f 20 62 65 20 69 6e |) may al|so be in|
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|00006220| 70 61 74 68 6f 70 68 79 | 73 69 6f 6c 6f 67 69 63 |pathophy|siologic|
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|00006240| 63 6f 6d 6d 6f 6e 20 74 | 6f 20 61 74 68 65 72 6f |common t|o athero|
|00006250| 73 63 6c 65 72 6f 73 69 | 73 20 61 6e 64 20 76 61 |sclerosi|s and va|
|00006260| 73 63 75 6c 69 74 69 73 | 2c 0d 0a 61 6c 74 68 6f |sculitis|,..altho|
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|00006280| 72 20 74 68 65 20 65 66 | 66 65 63 74 20 6f 63 63 |r the ef|fect occ|
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|000062c0| 0a 20 20 20 20 20 54 68 | 65 20 64 72 75 67 73 20 |. Th|e drugs |
|000062d0| 6d 6f 73 74 20 6f 66 74 | 65 6e 20 75 73 65 64 20 |most oft|en used |
|000062e0| 74 6f 20 74 72 65 61 74 | 20 76 61 73 63 75 6c 69 |to treat| vasculi|
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|00006370| 45 61 72 6c 79 20 64 69 | 61 67 6e 6f 73 69 73 20 |Early di|agnosis |
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+--------+-------------------------+-------------------------+--------+--------+
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